Modeling of Phamacokinetics and Pharmacodynamics of Novel Glucagon Analogues for Closed-Loop Dual Hormone Blood Glucose Control
Sabrina Lyngbye Wendt: The artificial pancreas is the future treatment of diabetes. The device will regulate blood glucose by co-administrating insulin and glucagon according to a control algorithm based on feedback from continuous glucose measurements. Natural endogenous glucagon is insoluble and therefore not possible to use in a pump.
This project will investigate pharmacokinetics and pharmacodynamics of a novel soluble glucagon analogue invented by Zealand Pharma A/S and simulate blood glucose control using a dual hormone closed-loop pump.
Effective start/end date 15/03/2014 → 16/08/2017
Published as PhD report: Modeling Pharmacokinetics and Pharmacodynamics of Glucagon for Simulation of the Glucoregulatory System in Patients with Type 1 Diabetes.
Supervisors: John Bagterp Jørgensen, Henrik Madsen
Section for Scientific Computing