Casper Bo Jensen: The project aims to add significant new insight into the abilities of different peptide protractions to affect the penetrance of medicinal compounds into the brain.
Potentially, the project could identify the best suited candidates with respect to targeting of specific brain centres. This knowledge can aid the development of GLP-1 analogues to drive improved treatment of obesity and Type II diabetes.
With regards to technological development, the project will allow the company and university to establish a 3D computer generated scaffold to fast and reliably quantify signal intensities in various tissue applicable with 3D imaging techniques. Such techniques are expected to provide superior sensitivity and specificity over currently employed techniques for analysing fluorescent signalling in complex biological sources.
Effective start/end date 01/09/2014 → 15/11/201
Published as PhD report: Quantitative evaluation of peptide analogue distribution in mouse tissue using 3D computer modelling
Supervisors: Anders Bjorholm Dahl, Knut Conradsen
Section for Visual Computing